Fig. 2

Ratio distribution of gene expression levels of parental and filial of aneuploid compared with diploid. a–d The distribution of gene expression ratios on the extra chromosomes (cis) of parental, filial primary trisomy 11 and 12, respectively. e–h The distribution of gene expression ratios on the other chromosomes (trans) of parental, filial primary trisomy 11 and 12, respectively. i and j The distribution of gene expression ratios on the extra chromosomes of T11-FN and T12-FN, respectively. k and l The distribution of gene expression ratios on the other chromosomes of T11-FN and T12-FN, respectively. The ratios were plotted with bins of 0.05 increments. X-axis represents the ratio bin of fold-change in gene expression levels and Y-axis represents the expressed gene (FPKM > 0) frequency per bin. A ratio of 1.00 and 1.50 represents the dosage compensation and dosage effect in cis, respectively. A ratio of 0.67 represents the inverse ratio of gene expression in trans. These ratio values are demarcated with labeled vertical lines in red (1.50), black (1.00) and yellow (0.67). m Hierarchical analysis of dysregulated genes from aneuploid and diploid was performed based on the expression patterns of genes showed dysregulated expression in at least one aneuploid (9,594 in total). Heatmap visualizing the hierarchical clustering of gene expression levels in each strains